Chromosomal integration of biosynthetic pathways for the production of high‐value chemicals is a necessity to develop industrial strains with a high long‐term stability and a low production variability. Here we present SIRE, Serine Integrase Recombinational Engineering, a novel methodology which combines the ease of recombinase mediated cassette exchange (RMCE) with the selectivity of orthogonal att sites of the Read more about SIRE: A versatile toolbox for genome editing[…]
The quest to find novel antibiotics is currently very difficult in a time where antimicrobial resistance is on the rise. By causing 25.000 deaths in the European Union alone, it is the sixth major death cause in the EU. In case too little novel antibiotics are developed, many surgical procedures will become increasingly risky and the Read more about Check our review in Biotechnology Advances: Hidden antibiotics: Where to uncover?[…]
In De Standaard verscheen dit weekend (6 en 7 oktober 2018) een artikel over de huidige problemen rond pastic vervuiling en hoe de industrie er momenteel mee omgaat. Ook professor Soetaert mocht zijn mening geven over dit actuele probleem. U kan het volledige nieuwsartikel hier terugvinden.
‘Classical’ biosurfactants produced by Starmerella bombicola contain oleic acid as the incorporated hydrophobic group. However, other chain lengths can (to a certain content) be incorporated by feeding the yeast with substrates of alternative chain lengths, be it with a lower efficiency. This is defined by the substrate specificity of the first enzymatic step in sophorolipid biosynthesis, Read more about New article published in Colloids and Interfaces on ‘Expression of Chimeric Cytochrome P450s’[…]
The AppliSurf INDUSTRY USER GROUP Kick-Off Event will be organised on 8 October 2018 at 9.30am in Ghent (Belgium). More information on this event can be found here. Registration is free but mandatory. Companies that wish to be involved in the user group can still join this VIS project by completing this form or contacting dr. Sophie Roelants.
Recently, our lab succeeded to produce bio-based glycolipid bolaamphiphile on a gram scale by using the genetically-engineered S. bombicola strain Δat Δsble Δfao1 (Van Renterghem et al., Biotechnol. Bioeng., 2018, 115, 1195–1206). This article show that the bio-based glyco-bolaamphiphile readily forms a hydrogel in water at room temperature, and that the hydrogel formation depends on the formation of self-assembled fibers. Here, you can find more information Read more about Article in ‘Soft Matter’ : Bio-based glyco-bolaamphiphile forms a temperature-responsive hydrogel with tunable elastic properties[…]
In 2019, a Massive Open Online Course (MOOC) will be kicked off, in which InBio.be is participating. The MOOC is organized by Bio Innovation Growth mega Cluster (BIG-Cluster). The BIG-Cluster aims at building a coordinated education and training initiative with focus on academic education in a cross-border approach with partners from the BIG-Cluster region: the Cross-border BioEconomy Education CROSSBEE. The MOOCs Read more about Coming soon: MOOC[…]
Currently, there is a lot of interest in bolaamphiphiles because of the unusual architecture created by such molecules as they possess not one but two hydrophilic heads, coupled by a hydrophobic linker. Only a limited amount of bolaamhiphiles can be produced microbially. Applying a combination of white biotechnology and green chemistry can dramatically increase the structural possibilities starting from Read more about A research article about bolaamphiphilic sophorolipids is published in ACS Sustainable Chemistry & Engineering[…]
A new article was published in the journal ‘Green Chemistry’. Herein, complex coacervation of micelles from a bolaform sophorolipid biosurfactant with oppositely charged cationic polyelectrolytes (i.e., chitosan oligosaccharide lactate, poly (L-lysine) and poly(allylamine)) was investigated. You can find the article here.