Saccharomyces cerevisiae (baker’s yeast or brewer’s yeast) is a popular microbial host in industrial biotechnology. Most synthetic biology tools to tune pathway expression focus on controlling transcription, whereas post‐transcriptional regulation is often overlooked. In this review, we discuss regulatory elements found in the 5′ untranslated region (UTR) and their influence on protein synthesis. Next to Read more about Check our newest review on 5’UTRs![…]
Until now, the production of microbial biosurfactants has been limited to the use of first-generation (food) substrates. Moreover, the results on sophorolipids yield and productivity reported by state-of-the-art fed-batch processes for sophorolipids production remain unsatisfactory and lead to a significantly high cost per kg of the product. With an aim to address these problems, this Read more about Article: “Efficient in-situ separation design for long-term sophorolipids fermentation with high productivity”[…]
Glucolipids (GLs) are glycolipid biosurfactants with promising properties, but up until today these interesting molecules could only be produced using an engineered Starmerella bombicola strain(∆ugtB1::URA3 G9) producing GLs instead of sophorolipids, albeit with a very low average productivity (0.01 g/L.h). In this study, we found that all glycolipid biosynthetic genes and enzymes were downregulated in Read more about New article published on glucolipid synthesis in S. bombicola![…]
Check our newest article in FEMS Yeast Research! In this article, the one-step microbial production of hydroxy fatty acids by S. bombicola was accomplished by the selective blockage of three catabolic pathways through metabolic engineering. Successful production of 17.39 g/l (ω-1) linked hydroxy fatty acids was obtained by the successive blockage of the sophorolipid biosynthesis, the Read more about New article: ‘Production of long-chain hydroxy fatty acids by Starmerella bombicola’[…]
Last week our rock-star LipoActives team joined the biosurfactants congress in Stuttgart – Germany. They return with new inspirations and a lot of motivation for their state-of-the-art sophorolipid research!
Click here to read Prof. Wim Soetaert ‘s last column, published in Petrochem 09-2019.
Biobased Surfactants: Synthesis, Properties, and Applications, Second Edition, covers biosurfactant synthesis and applications and demonstrates how to reduce manufacturing and purification costs, impurities, and by-products. Fully updated, this book covers surfactants in biomedical applications, detergents, personal care, food, pharmaceuticals, cosmetics, and nanotechnology. It reflects on the latest developments in biobased surfactant science and provides case Read more about Check our new book chapter in ‘Biobased Surfactants – 2nd Edition’[…]
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In this article, the production of biosurfactant sophorolipids from several (food) waste streams was investigated, using the non-pathogenic yeast Starmerella bombicola. From a preliminary screening, restaurant food waste emerged as the most suitable feedstock compared to bakery waste, textile waste, used corn oil, animal fat and lipid fraction of hydrolyzed food waste. Restaurant food Read more about Article: Efficient sophorolipids production using food waste[…]